What About Brian follows a close-knit group of friends in Los Angeles who are in various stages of relationships. All of the friends has paired off, except for Brian. Brian is living the single life but the only problem is he is secretly harboring a crush on his best friend's girlfriend.
Serial monogamist Brian O'Hara hits his mid-30s and suddenly realizes he's the last bachelor standing in his circle of friends. Not averse to the happily ever after his friends have achieved, Brian wonders whether he'll ever find Mrs. Right. The fact that he's in love with his best friend's girlfriend doesn't help his chances.