A promotional image featuring Richard Webber (James Pickens Jr.), Miranda Bailey (Chandra Wilson), and Meredith Grey (Ellen Pompeo).

Grey's Anatomy scrubs in for more high-stakes drama on Disney+

by Explore Disney+ Contributor

9 April 2026

Meredith Grey and her fellow surgeons return for an all-new chapter of life, love, and medicine at Grey Sloan Memorial

Few series balance pulse-pounding cases with heartfelt character moments like Grey's Anatomy, and season 22, anchored by Ellen Pompeo’s enduring performance, promises even more of the intense hospital drama that fans love. The new season is now here, and longtime favourites and fresh faces alike are ready to test the limits of both their scalpel skills and personal bonds at Grey Sloan Memorial.

When did Grey's Anatomy season 22 premiere?

Season 22 of the long-running series premiered 10 October on Disney+ in the UK.

What’s the plot of Grey's Anatomy season 22?

The high-intensity medical drama follows Dr. Meredith Grey (Ellen Pompeo) and the dedicated staff of Grey Sloan Memorial Hospital as they make life-or-death decisions every day. Season 22 follows on from the explosive finale of the previous season and continues the show’s signature blend of complex surgeries, evolving relationships, and ethical dilemmas that refuse to be defined in black and white.

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Who’s in the Grey's Anatomy season 22 cast?

Returning talent includes Ellen Pompeo, Chandra Wilson, James Pickens Jr., Kevin McKidd, Caterina Scorsone, Camilla Luddington, Kim Raver, Chris Carmack, Anthony Hill, Jason George, Alexis Floyd, Harry Shum Jr., Adelaide Kane, Niko Terho, and Trevor Jackson.

Who are the characters in Grey's Anatomy season 22?

  • Ellen Pompeo as Dr. Meredith Grey

  • Chandra Wilson as Dr. Miranda Bailey

  • James Pickens Jr. as Dr. Richard Webber

  • Kevin McKidd as Dr. Owen Hunt

  • Caterina Scorsone as Dr. Amelia Shepherd

  • Camilla Luddington as Dr. Jo Wilson

  • Kim Raver as Dr. Teddy Altman

  • Chris Carmack as Dr. Atticus “Link” Lincoln

  • Anthony Hill as Dr. Winston Ndugu

  • Jason George as Dr. Ben Warren

  • Alexis Floyd as Simone Griffith

  • Harry Shum Jr. as Benson “Blue” Kwan

  • Adelaide Kane as Jules Millin

  • Niko Terho as Lucas Adams

  • Trevor Jackson as Wes

Who’s behind Grey's Anatomy season 22?

Season 22 is steered by executive producer and showrunner Meg Marinis alongside creator Shonda Rhimes, executive producers Betsy Beers, Mark Gordon, Ellen Pompeo, Debbie Allen, Zoanne Clack, and Mark Driscoll.

Where was Grey's Anatomy season 22 filmed?

Production took place in Los Angeles, California.

The season 22 premiere of Grey's Anatomy is now streaming on Disney+. Add the series to your Watchlist and stay up-to-date with each new case at Grey Sloan Memorial.

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