All of humanity is instantly turned to stone by a mysterious phenomenon. Thousands of years later, Senku, a science-minded boy with a superhuman brain, awakens from his stone slumber. Realizing that life on earth as he knew it has ended in this new Stone World, he vows to retake humanity with the sheer power of science. Around the same time, his childhood friend Taiju Oki, who prides himself of physical endurance, manages to break free from the stone. The two friends set about recreating civilization from scratch as they use two million years of scientific knowledge to help the world escape the Stone Age. And so, begins an unprecedented crafting adventure!